Modern Methods of Organic Synthesis

The course presents the most important reaction types as tools for research scientist to use in synthesis. Topics include formation of carbon-carbon bonds, molecular rearrangement, cycloaddition and pericyclic reactions, photochemical and free radical reactions, oxidation and reduction reactions with emphasis on chemo-, regioand stereoselectivity. General principles of retrosynthetic analysis will be used to design simple synthetic schemes for synthesis of target molecules, including important natural products. Prerequisite: CHM 222. CHM 427 Pharmaceutical Chemistry (3.0); 3 cr. This course explores in depth the synthesis of pharmaceutically important molecules such as antibiotics, cardiovascular, anti-inflammatory, chemotherapeutic agents and more. Special attention is placed on the strategy and tactics in synthesis and reaction mechanisms. Real case studies of process development of drug substances in pharmaceutical industry will be illustrated to show the problems which may be encountered in scaling up chemical synthesis and the ways these problems may be overcome. Prerequisite: CHM 425. properties of food components and additives. It covers the processing operations of important food classes (beverages, fruits and vegetables, dairy products), major chemical changes taking place during processing and storage of foods, and principal methods of analysis used in the food industry. Prerequisite: CHM 222. HM